意大利研究者最近研究找到了高胆固醇与前列腺癌直接相关证据，虽然证据有限，但研究结果揭示这两者
之间有着很显著的关联。
该研究涉及1991-2002年意大利的1294名75岁以下患有前列腺癌的男性患者及1451名非前列腺癌患者作为
对照组。调查结果表明，与对照组相比，50%的前列腺癌患者胆固醇偏高，这种关联程度要高于男性在50
岁前被诊断为高胆固醇及在65岁被诊断为高胆固醇的概率。同时，研究也发现前列腺癌患者患有胆结石的
比例比对照组高26%的，对于较瘦的男性更为明显。尽管前列腺癌患和胆结石的关联程度在统计学上并不
是十分显著，但胆结石通常与高胆固醇相关。
Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate
cancer
F. Bravi 1 *, L. Scotti 1, C. Bosetti 1, R. Talamini 2, E. Negri 1, M. Montella 3, S.
Franceschi 4, and C. La Vecchia 5
1 Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan, Italy
2 Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN),
Italy
3 Servizio di Epidemiologia, Istituto Tumori ‘Fondazione Pascale’, Naples, Italy
4 International Agency for Research on Cancer, Lyon Cedex, France
5 Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan, Italy; Istituto di Statistica
Medica e Biometria, Università degli Studi di Milano, Milan, Italy
* To whom correspondence should be addressed.
F. Bravi, E-mail: bravi@marionegri.it
Abstract
Background: Although prostate cancer is one of the most common male cancers, its
aetiology--and particularly the role of comorbidity--remains poorly understood.
Patients and methods: Between 1991 and 2002, a case-control study on prostate cancer was
conducted in Italy. This included 1294 men under the age of 75 years with incident,
histologically confirmed prostate cancer, and 1451 controls, admitted to the same hospitals
as cases for a wide spectrum of acute, non-neoplastic diseases. The subjects' self-reported
history of selected medical conditions was assessed through a structured and satisfactorily
reproducible questionnaire. Multivariate odds ratios (ORs) and 95% confidence intervals
(CIs) were obtained after allowance for major potential confounding factors.
Results: A significant direct relation was observed between hypercholesterolaemia and
prostate cancer (OR = 1.51, 95% CI 1.23-1.85). This association was stronger (OR = 1.80) in
older subjects (age 65) than in younger ones (OR = 1.32). A non-significant excess risk of
prostate cancer was also observed for gallstones (OR = 1.26, 95% CI 0.93-1.70) and the
relation was apparently stronger in patients with lower body mass index (OR = 1.59).
Conclusions: This study suggests a possible relation between hypercholesterolaemia and
prostate cancer.
Keywords: case-control study; cholesterol; medical history; prostate cancer.
Direct link between high cholesterol levels and prostate cancer
Medical Studies/Trials
Published: Thursday, 13-Apr-2006
