In 2008 the estimated age-adjusted annual incidence of breast cancer in Europe (40 countries) was 88.4/100 000 and the mortality 24.3/100000. The incidence is increasing due to mammographic screening and an aging population; postmenopausal hormone replacement therapy, Western-style diet, obesity and consumption of alcohol and tobacco contribute to the rising incidence of breast cancer. There is a steep age gradient, with about a quarter of breast cancers occurring before age 50, and <5% before age 35. In most Western countries, the mortality rate has decreased in recent years, especially in younger age groups because of improved treatment and earlier detection. However, breast cancer is still the leading cause of cancer-related deaths in European women.
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