Cancer Lett 2011 Dec;313 (2): 129-36. [IF:4.864]
Hypoxia, stem cells and bone tumor.
Zeng W , Wan R , Zheng Y , Singh SR , Wei Y .
Department of Orthopaedics, Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China; Department of Orthopaedics, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China.
上海交通大学医学院，瑞金医院骨科，上海第一人民医院
Abstract
Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors. The hypoxia inducible factors (HIFs) are the key mediators of the cellular response to hypoxia. In this review, we focused on the role of HIFs on bone tumor formation. Further, we also emphasized how hypoxia, stem cells, and its niches regulate the bone tumorigenesis.
