He, L; Thomson, JM; Hemann, MT; Hernando-Monge, E; Mu, D; Goodson, S; Powers, S; Cordon-Cardo, C; Lowe, SW; Hannon, GJ; Hammond, SM Nature 2005,435(7043)828-833 引用次数 1079
这篇发表于2005年的Nature杂志报道了miRNA簇mir- 17 - 92 cluster在B细胞淋巴瘤中高表达，并与癌基因c-myc高表达相关，提示mir- 17 - 92 cluster为潜在的癌基因。
【摘要】To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, noncoding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas(1). Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir- 17 - 92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir- 17 - 92 cluster as a potential human oncogene.
免费下载原文http://www.gs.washington.edu/academics/courses/braun/55105/readings/lin.pdf
